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|Title: ||PROJECT FIGHT 2 - Development of an Edible Bait Vaccine to Control Rabbit Haemorrhagic Disease Virus 2 (RHDV2) in Wild Rabbits|
|Authors: ||Carvalho, CL|
São Brás, B
Roldão A, A
|Keywords: ||Oryctoalgus cuniculus algirus|
|Issue Date: ||Sep-2019|
|Publisher: ||1st ICECVM – Athens, Greece, 26th-27th September 2019.|
|Citation: ||PROJECT FIGHT 2 - Development of an Edible Bait Vaccine to Control Rabbit Haemorrhagic Disease Virus 2 (RHDV2) in Wild Rabbits. Carvalho CL , Monteiro M, Carvalho P, Mendonça P, Correia J, São Brás B, Peleteiro C, Duarte E, Mira A, Branco S, Roldão A, Duarte MD. 1st ICECVM – Athens, Greece, 26th-27th September 2019.|
|Abstract: ||PROJECT FIGHT-TWO - EDIBLE BAIT VACCINE FOR RABBIT HAEMORRHAGIC DISEASE VIRUS 2
(RHDV2) CONTROL IN WILD RABBITS
Carina L. Carvalho1,2, Madalena Monteiro1, Paulo Carvalho1, Paula Mendonça1, Jorge Correia3,
Berta São Brás, Conceição Peleteiro 2, Elsa Duarte3, António Mira3, Sandra Branco 3, António
Roldão4, Margarida D. Duarte1,2
1-Instituto Nacional de Investigação Agrária e Veterinária Av. da República, Quinta do Marquês
2-ICAAM – Instituto de Ciências Agrárias e Ambientais Mediterrânicas, Instituto de Formação e
Investigação Avançada, Universidade de Évora. Pólo da Mitra, Ap. 94, 7006-554 Évora
3-CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade
Técnica, 1300-477 Lisboa
4- IBET – Instituto de Biologia Experimental e Tecnológica, Avenida da República, Estação
Agronómica, 2780-157 Oeiras
Rabbit haemorrhagic disease (RHD) is a highly contagious and often lethal systemic infection in
the European rabbit (Oryctolagus cuniculus). Presently, the condition is caused by the rabbit
haemorrhagic disease virus 2 (RHDV2), which replaced the classical RHDV genogroups (G1-G6)
after its emergence in 2010, and continues to cause great concerns on the conservation of the
diminished Iberian wild rabbit populations, directly impacting on several endangered species
that depend on the rabbit for survival.
The commercial RHDV2 vaccines available to date are inactivated, obtained from infected
animal liver extracts and the route of administration is usually subcutaneous, requiring handling.
Further than the risks associated with incomplete virus inactivation and the inadvertent release
of infectious virus, these vaccines are not suitable for wild rabbits, requiring capture for
inoculation. The immunity is short and, hence, the protection transient. The previous
commercial RHDV vaccines, most also inactivated, were shown to be ineffective in conferring
cross protection against RHDV2.
The FIGHT-TWO strategic framework is the development and production of a new edible vaccine
against RHDV2 which is presently disseminated in the entire territory of Portugal, including the
insular regions. The safe, pathogen-free RHDV2 oral vaccine is to be distributed in the field as
bait or included in dry feed. This non-invasive immunization has the potential to protect a broad
proportion of the populations, crucial to stop virus transmission and control the infection, while
overcoming the need of capture and manipulation.
The virus-like particle (VLP)-based vaccine will be produced in insect cells-baculovirus expression
vector system (IC-BEVS) and updated accordingly to RHDV2 evolution (open system). To
accomplish FIGHT-TWO objectives, INIAV, the reference laboratory for animal diseases, join
forces with IBET, UE and FMV.
FIGHT-TWO will allow to proceed with one of the 12 measures specified in the Action Plan for
the Control of Rabbit Hemorrhagic Viral disease in Rabbits (Dispatch 4757/17 of 31 May).
Obtaining this vaccine will be crucial to support more generalist wild rabbit management policies
towards the recovery of population densities and disease control, the recovery of ecosystems
where the rabbit is keystone and the reactivation of hunting activities in Portugal.
Keywords (max: 6): Oryctoalgus cuniculus algirus, wild rabbit, RHDV2, oral vaccine, VP60-VLPs,
Acknowledgments: PTDC/CVT-CVT/29062/2017-PT2020; Partnership +Coelho|
|Appears in Collections:||MED - Comunicações - Em Congressos Científicos Internacionais|
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