Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/36718

Title: Multicomponent (bio) markers for obesity risk prediction: a scoping review protocol.
Authors: Vahid, Farhad
Dessenne, Coralie
Tur, Josep
Bouzas, Cristina
Devaux, Yvan
Malisoux, Laurent
Turner, Jonathan
Lamy, Elsa
Pérez-Jiménez, Maria
Ravn-Haren, Gitte
Andersen, Rikke
Forberger, Sarah
Nagrani, Rajini
Ouzzahra, Yacine
Fontefrancesco, Michele Filippo
Onorati, Maria Giovana
Bonetti, Gino Gabriel
de-Magistris, Tiziana
Bohn, Torsten
Keywords: Obesity
PUBLIC HEALTH
Behavior
Quality of Life
Primary Prevention
Issue Date: 8-Mar-2024
Publisher: BMJ Open
Citation: Vahid F, Dessenne C, Tur JA, et alMulticomponent (bio)markers for obesity risk prediction: a scoping review protocolBMJ Open 2024;14:e083558. doi: 10.1136/bmjopen-2023-083558
Abstract: Introduction Despite international efforts, the number of individuals struggling with obesity is still increasing. An important aspect of obesity prevention relates to identifying individuals at risk at early stage, allowing for timely risk stratification and initiation of countermeasures. However, obesity is complex and multifactorial by nature, and one isolated (bio)marker is unlikely to enable an optimal risk stratification and prognosis for the individual; rather, a combined set is required. Such a multicomponent interpretation would integrate biomarkers from various domains, such as classical markers (eg, anthropometrics, blood lipids), multiomics (eg, genetics, proteomics, metabolomics), lifestyle and behavioural attributes (eg, diet, physical activity, sleep patterns), psychological traits (mental health status such as depression) and additional host factors (eg, gut microbiota diversity), also by means of advanced interpretation tools such as machine learning. In this paper, we will present a protocol that will be employed for a scoping review that attempts to summarise and map the state-of-the-art in the area of multicomponent (bio)markers related to obesity, focusing on the usability and effectiveness of such biomarkers. Methods and analysis PubMed, Scopus, CINAHL and Embase databases will be searched using predefined key terms to identify peer-reviewed articles published in English until January 2024. Once downloaded into EndNote for deduplication, CADIMA will be employed to review and select abstracts and full-text articles in a two-step procedure, by two independent reviewers. Data extraction will then be carried out by several independent reviewers. Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews and Peer Review of Electronic Search Strategies guidelines will be followed. Combinations employing at least two biomarkers from different domains will be mapped and discussed. Ethics and dissemination Ethical approval is not required; data will rely on published articles. Findings will be published open access in an international peer-reviewed journal. This review will allow guiding future directions for research and public health strategies on obesity prevention, paving the way towards multicomponent interventions.
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928751/
http://hdl.handle.net/10174/36718
Type: article
Appears in Collections:MED - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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