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http://hdl.handle.net/10174/30926
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Title: | Recent Advances in Asymmetric Hydrogenation Catalysis Utilizing Spiro and Other Rigid C-Stereogenic Phosphine Ligands |
Authors: | Burke, Anthony Herrmann, Gesine Federsel, Hans-Jurgen |
Editors: | Miller, Scott |
Keywords: | Asymmetric catalysis Hydrogenation API |
Issue Date: | 27-Sep-2021 |
Publisher: | American Chemical Society |
Abstract: | Transition-metal-catalyzed asymmetric reactions have been a powerful tool in organic synthesis for many years. The design of chiral ligands with the right configuration is fundamental to induce high regio- and stereoselectivity to catalytic reactions and to achieve high turnover numbers and high yields. A challenge is the control of prochiral centers with similar electronic properties in a similar steric environment within the same molecule. Over the last 10 years, a range of novel rigid C-stereogenic chiral phosphine ligands has been developed and successfully applied in various types of asymmetric transformations. Many of these ligands are of a di-, tri-, or multidentate nature. The purpose of this Perspective is to highlight recent synthetic achievements (since 2010) with spiro-phosphines and other rigid phosphines and discuss some mechanistic aspects of the catalytic reactions. |
URI: | https://pubs.acs.org/doi/10.1021/acs.joc.1c01571 http://hdl.handle.net/10174/30926 |
Type: | article |
Appears in Collections: | LAVQ-REQUIMTE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
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