Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/24990

Title: Comparison of salivary proteome of children with different sensitivities for bitter and sweet tastes: association with body mass index
Authors: Rodrigues, Lénia
Espanca, Rosa
Costa, Ana Rodrigues
Antunes, Célia Miguel
Pomar, Clarinda
Capela e Silva, Fernando
Pinheiro, Cristina Conceição
Domingues, Pedro
Amado, Francisco
Lamy, Elsa
Keywords: salivary proteome
children
bitter taste
sweet taste
body mass index
Issue Date: 19-Dec-2018
Publisher: Nature Research
Citation: Rodrigues L, Espanca R, Costa AR, Antunes CM, Pomar C, Capela-Silva F, Pinheiro CC, Domingues P, Amado F, Lamy E. Comparison of salivary proteome of children with different sensitivities for bitter and sweet tastes: association with body mass index. Int J Obes (Lond). 2018 Dec 19. doi: 10.1038/s41366-018-0289-5.
Abstract: Background/objectives Oral sensorial perception is a key aspect in food choices and knowing the mechanisms modulating such perception is of major importance in the context of child obesity, which is reaching high rates in Mediterranean countries. Salivary proteome has been linked to taste sensitivity in adults. The aim of this study was to search for differences in salivary proteomes of children with different bitter or sweet taste sensitivities and to assess if these potential differences are associated with their body mass index percentile (BMI percentile). Subjects/methods 387 children aged 8–9 years old were assessed for BMI percentile and classified according to their sensitivity to bitter and sweet tastes, according to their caffeine and sucrose detection thresholds, respectively. Saliva protein composition was compared among taste sensitivity groups, taking into account BMI percentile and gender, using gel-based proteomics approaches, coupled to mass spectrometry for protein identification. Results Among the salivary proteins related to bitter taste sensitivity, higher levels of cystatins were observed in bitter-sensitive children, in the case of those of normal weight, and in bitter low-sensitive, in the case of overweight children. For sweetness, the relationship between saliva and taste perception was also dependent on BMI percentile, with several proteins (including salivary cystatins) differing between taste sensitivity groups, with disparities arising between normal-weight and overweight children. Cystatin isoforms A, B and SA were observed to be considerably increased in saliva from obese children. Conclusions Salivary proteome is related with sensitivities to bitter and sweet tastes in children, but the association is dependent on BMI percentile and gender.
URI: https://www.nature.com/articles/s41366-018-0289-5#Sec20
http://hdl.handle.net/10174/24990
Type: article
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