Please use this identifier to cite or link to this item:

Title: Long term betaine supplementation regulates genes involved in lipid and cholesterol metabolism of two muscles from an obese pig breed
Authors: Albuquerque, A.
Neves, José A
Redondeiro, M.
Laranjo, Marta
Félix, M.R.
Freitas, Amadeu
Tirapicos, José L
Martins, José M
Keywords: Betaine
Longissimus lumborum
Biceps femoris
Intramuscular fat and cholesterol content
Gene expression
Alentejano pig
Issue Date: 2017
Citation: Albuquerque, A.; Neves, José A; Redondeiro, M.; Laranjo, M.; Félix, M.R.; Freitas, Amadeu; Tirapicos, José L; Martins, José M. Long term betaine supplementation regulates genes involved in lipid and cholesterol metabolism of two muscles from an obese pig breed, Meat Science, 124, 25-33, 2017.
Abstract: This study evaluates the effects of betaine supplementation (1 g kg−1 for 20 weeks) on the regulation of genes involved in lipid and cholesterol metabolism of Longissimus lumborum and Biceps femoris from obese Alentejano pigs. Betaine supplementation led to an increase in total cholesterol in both muscles, complementing results previously published indicating a significant increase on the intramuscular lipid content. The expression of twelve genes involved in lipogenesis, lipolysis/FA oxidation, FA transport, and cholesterol metabolism, as well as two transcription factors were also evaluated. Genes related to lipid and cholesterol synthesis plus FA transport were consistently up-regulated in both muscles of betaine fed pigs. On the other hand, genes related to lipolysis/FA oxidation were not affected or down-regulated by betaine supplementation. Our data suggest that the underlying mechanism regulating IMF and cholesterol accumulation in Alentejano pigs supplemented with betaine is associated with the up-regulation of genes involved in lipid synthesis, FA transport, and cholesterol synthesis.
URI: 03091740
Type: article
Appears in Collections:MED - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

Files in This Item:

File Description SizeFormat
2017_Meat Sci_1-s2.0-S0309174016304260-main.pdf66.74 kBAdobe PDFView/Open
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Dspace Dspace
DSpace Software, version 1.6.2 Copyright © 2002-2008 MIT and Hewlett-Packard - Feedback
UEvora B-On Curriculum DeGois