Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/16575

Title: Hormonal, luteal, and follicular changes during initiation of persistent corpus luteum in mares
Authors: Santos, Vanda Gonçalves
Bettencourt, Elisa Maria
Ginther, Oliver J
Editors: Elsevier
Keywords: CL
Estradiol
Persistent CL
PGF2α
Progesterone
Issue Date: 1-Mar-2015
Publisher: Elsevier
Citation: Santos, V. G., Bettencourt, E. M., & Ginther, O. J. (2015). Hormonal, luteal, and follicular changes during initiation of persistent corpus luteum in mares. Theriogenology, 83(4), 757-765.
Abstract: Mares with persistent CL (PCL) with no known etiology (idiopathic) were matched with mares with an interovulatory interval (IOI) of apparent physiological length, so that ovulation at the beginning of each PCL and IOI occurred during the same month (n = 6/group). Blood samples were collected daily from Days 12 to 22 (Day 0 = ovulation). Mean progesterone (P4) decreased in both groups on Days 14 and 15 and then diverged with a continued decrease in the IOI group and the beginning of constant and greater (P < 0.05) P4 concentration on each day in the PCL group. Before P4 divergence between groups, P4 in the PCL group decreased either abruptly (apparent incomplete luteolysis) or gradually. Concentration of PGFM (a metabolite of PGF2α) was not different between groups and reached maximum on mean Day 15 in each group. After the divergence in P4 between groups, LH and estradiol (E2) remained low in the PCL group. There was no indication that an increase in a luteotropic effect of LH in the PCL group accounted for the divergence in P4. Differences in prolactin between the groups were inconclusive. The hypothesis that secretion of PGF2α at the time of expected luteolysis is defective in mares with idiopathic PCL was not supported. The hypothesis that E2 concentration before expected luteolysis is greater in mares with PCL than those without PCL was not supported; however, a difference on Day 12 approached significance (P < 0.06) and tentatively indicated greater E2 in the PCL group before the beginning of luteolysis.
URI: http://www.sciencedirect.com/science/article/pii/S0093691X1400613X
http://hdl.handle.net/10174/16575
Type: article
Appears in Collections:ICAAM - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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