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Title: Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri
Authors: Arantes, Silvia
Candeias, M. Fátima
Pereira, Marizia
Lopes, Orlando
Lima, Mónica
Martins, M. Rosário
Editors: Correia, A. C. M.
Coimbra, M. A.
Keywords: Lavandula stoechas ssp. luisieri
essential oil
toxicological evaluation
farmacological actvity
Issue Date: Dec-2013
Publisher: Universidade de Aveiro
Citation: Arantes S, Candeias MF, Pereira M, Lopes, O., Lima, M., Cruz-Morais J., Martins MR (2013). Toxicological and pharmacological evaluation of the essential oil and aqueous extract of Lavandula stoechas L. subsp. luisieri. Livro de Resumos do MicroBiotec, pp 303, Aveiro, Portugal
Abstract: Lavenders belong to the family Labiatae and represent some of the most popular medicinal plants extensively used in aromatherapy. In this study, we selected Lavandula stoechas L. subsp. luisieri (Rozeira) Rozeira, endemic of Portugal, collected in Évora (Alentejo). The aim of this study was to evaluate the acute toxicity and the analgesic and anti-inflammatory activities of the essential oil and aqueous extract from leaves of L. luisieri. The essential oil was obtained by hydrodistillation in Clevenger type apparatus and the resulting hydrolate was lyophilized. Chemical composition of essential oil was evaluated by GC/FID and extract was characterized by phytochemical tests and total phenolics and flavonoids quantification. Acute toxicity was evaluated in vitro in brine shrimp (LC50) and in vivo in Swiss mice, by pharmacological screening, determination of LD50, according to Up-and-Down OECD Procedure and liver and kidney histopathological study. Pharmacological properties, namely, analgesic and anti- inflammatory activities were evaluated in rats.
Type: article
Appears in Collections:MED - Artigos em Livros de Actas/Proceedings

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