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|Title: ||BoImAr: Borylation(Catalytic)-Imination-Arylation(Catalytic) - A New Synthetic Approach to Promising Alzheimer and Parkinson Drugs|
|Authors: ||Mendes, Paulo J.|
Burke, Anthony J.
|Issue Date: ||2013|
|Publisher: ||Sociedade Portuguesa de Química|
|Citation: ||Daniela Peixoto, . Marques, Paulo J. Mendes, Anthony J. Burke, “BoImAr: Borylation(Catalytic)-Imination-Arylation(Catalytic) - A New Synthetic Approach to Promising Alzheimer and Parkinson Drugs”, 10º Encontro Nacional de Química Orgânica, 1º Simpósio Luso-Brasileiro de Química Orgânica, September 4-6, 2013, Lisbon, Portugal, Book of Abstracts PC99|
|Abstract: ||Although dramatic progress has been made in understanding the pathogenesis of neurodegenerative conditions of the aged population such as Alzheimer's disease, Parkinson's disease and Fronto-Temporal dementia, to date most of these diseases are incurable. Because of the aging population, these disorders pose a serious challenge to the health care system. Loss of synapses is probably the common neuropathological feature leading to dementia in these neurodegenerative disorders.1
Parkinson's disease is a progressive neurodegenerative condition caused by loss of dopamine producing cells in the substantia located in the basal ganglia causing motor, autonomic and cognitive impairments.2 Rasagiline is a potent, selective, irreversible inhibitor of monoamine oxidase (MAO) which is an anti-Parkinson drug.3
Herein, we present our innovative approach to the synthesis of several chiral amine4 -benzolactam analogues which involves a one-pot borylation-Imination-Arylation (BoImAr) sequence - the last step being a key intramolecular catalytic arylation reaction.|
|Appears in Collections:||QUI - Comunicações - Em Congressos Científicos Nacionais|
CQE - Comunicações - Em Congressos Científicos Nacionais
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