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Title: Antispasmodic activity of aqueous extracts from Mentha x piperita native from Trás-os-Montes region (Portugal)
Authors: Moutinho, Carla
Matos, Carla
Neves, José Manuel
Teixeira, Dora Martins
Cunha, Sílvia
Gomes, Lígia Rebelo
Editors: Shekhar, VA
Keywords: Mentha x piperita, phenolic content, antispasmodic activity , cytotoxicity, antioxidant activity
Issue Date: 2014
Publisher: International Journal of Indigenous Medicinal Plants
Citation: Carla Moutinho, Carla Matos, José Manuel Neves, Dora Martins Teixeira, Sílvia Cunha, Lígia Rebelo Gomes, Antispasmodic activity of aqueous extracts from Mentha x piperita native from Trás-os-Montes region (Portugal), International Journal of Indigenous Medicinal Plants, 29 1167-1174 (2014).
Abstract: The wild mint Mentha x piperita (Mentha rotundifolia Huds.), has been used by the local people in a northern region of Portugal to prepare infusions for treating digestive pain and spasms, as an appetite stimulant and for treating headache and migraine. This suggests that these aqueous extracts have analgesic; antispasmodic and stomachic properties. In the present study the antioxidant potential of aqueous extracts of Mentha x piperita is investigated since natural antioxidants can scavenge the reactive oxygen species, ROS, and thus might attenuate inflammation pathways. The antispasmodic activity was also checked. The antioxidant potential of the extract was evaluated by the DPPH• method, by the quantification of the total phenolic compounds and by characterization of the main phenolic compounds. The antispasmodic effects were investigated by performing pharmacological assays using the distal ileum of guinea pigs. The aqueous extract exhibits antioxidant properties that may be due to its phenolic content. The main phenolic compounds were quinic, caffeic, rosmarinic and chlorogenic acids. The antispasmodic affects are observed after electrical stimulation of segments of distal ileum of guinea pigs and may be attributed, at least, to a 1 blockage.
ISSN: 2051-4263
Type: article
Appears in Collections:QUI - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
HERCULES - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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