Please use this identifier to cite or link to this item:
|Title: ||The role of acetylcholinesterase in Alzheimer’s disease: Enzymatic inhibition studies|
|Authors: ||Bacalhau, P.|
|Editors: ||Oliveira, P.|
Ambrósio F., F.
|Keywords: ||Alzheimer’s disease|
|Issue Date: ||Dec-2014|
|Publisher: ||CNCB UC Editions|
|Citation: ||Bacalhau P., Marques C., Martins M. R., Caldeira A.T., Burke A. J. (2014) The role of acetylcholinesterase in Alzheimer’s disease: enzymatic inhibition studies. Proceedings of the XVIII Congress of the Portuguese Biochemical Society, (Oliveira P., Ambrósio F., Vega-Naredo I., Laranjinha J., Oliveira T., Serafim T., Sardão V. Eds) CNCBUC Editions, Coimbra, pp.73|
|Abstract: ||Alzheimer’s disease (AD) is the most common form of dementia and causes a progressive and irreversible neurodegeneration. It is related
with loss of cholinergic function, which affects memory, learning and behavior . Neurophathologically, AD is characterized by the presence
of beta-amyloid plaques (A ) and neurofibrillary tangles (NFT)  and consequent degeneration of the basal forebrain cholinergic neurons
. The loss of cholinergic neurons leads to the progressive reduction of acetylcholine (ACh) in the brain and resulting cognitive impairment
in AD . As such, the enzyme acetylcholinesterase (AChE) has been one of the prime targets in search for a treatment for AD, which uses
reversible inhibitors of AChE, in order to increase levels of acetylcholine (ACh) in the brain .
In the present study a small library of quinolinone and indole derivatives was screened for their eeAChE inhibitory activity using the Ellman
|Appears in Collections:||CQE - Artigos em Livros de Actas/Proceedings|
MED - Artigos em Livros de Actas/Proceedings
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.