Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/24548

Title: Effects of hyperleptinemia in rat saliva composition, histology and ultrastructure of the major salivary glands
Authors: Lamy, Elsa
Neves, S
Ferreira, J
Rodrigues, Lénia
da Costa, G
Cordeiro, C
Fialho, Luisa
Lima, Mónica
Costa, Ana R.
Antunes, Célia M.
Lopes, Orlando
Amado, F
Capela e Silva, Fernando
Keywords: Amylase
Leptin
Salivary glands
Salivary proteomics
Issue Date: 2018
Publisher: Elsevier
Citation: Lamy E, Neves S, Ferreira J, Rodrigues L, da Costa G, Cordeiro C, Fialho L, Lima M, Costa AR, Antunes CM, Lopes O, Amado F, Capela E Silva F. Effects of hyperleptinemia in rat saliva composition, histology and ultrastructure of the major salivary glands. Arch Oral Biol. 2018; 96:1-12.
Abstract: OBJECTIVE: To study the effect of the satiety hormone, leptin, in saliva proteome and salivary gland histology and ultrastructure. DESIGN: Increases in blood leptin levels were induced through mini-pump infusion in male Wistar rats, during a period of 7 days. Saliva was collected before and at the end of the experimental period, for proteomic analysis, and major salivary glands were collected, at the end, for biochemical, histological and ultrastructural analysis. RESULTS: Immunohistochemistry revealed the presence of leptin receptors in major salivary glands. Salivary amylase levels and enzymatic activity were decreased in saliva, whereas the enzymatic activity of this protein was increased in the cytosol of parotid gland cells. Transmission electron microscopy allowed the observation of high number of electron-dense granules in cytosol of parotid acinar cells, from leptin treated animals. CONCLUSIONS: Increased levels of plasmatic leptin result in changes in saliva composition and salivary glands function. To our knowledge, this is the first study providing evidences for a potential role of leptin in salivary gland secretion and saliva composition. An understanding of how appetite/satiety factors influence saliva composition and how this composition influences food processing in mouth may be relevant in understanding ingestive behaviour.
URI: https://www.sciencedirect.com/science/article/pii/S000399691830503X?via%3Dihub
http://hdl.handle.net/10174/24548
Type: article
Appears in Collections:BIO - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

Files in This Item:

File Description SizeFormat
Effects of hyperleptinemia in rat saliva composition....pdf73.22 kBAdobe PDFView/Open
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Dspace Dspace
DSpace Software, version 1.6.2 Copyright © 2002-2008 MIT and Hewlett-Packard - Feedback
UEvora B-On Curriculum DeGois