Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/19835

Title: Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoechas subsp. luisieri.
Authors: Arantes, Sílvia
Candeias, Fátima
Lopes, Orlando
Lima, Mónica
Pereira, Marízia
Tinoco, Teresa
Cruz-Morais, Júlio
Martins, M. Rosário
Keywords: Lavandula luisieri
Lamiaceae
essential oils
antioxidant
antimicrobial
analgesic
anti-inflammatory
Issue Date: 28-Apr-2016
Publisher: Georg Thieme Verlag KC
Citation: - Sílvia Arantes, Fátima Candeias, Orlando Lopes, Mónica Lima, Marízia Pereira, Teresa Tinoco, J. Cruz-Morais, M. Rosário Martins. (2016). Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoechas subsp. luisieri. Planta Medica, 82: 1266-1273. DOI 10.1055/s-0042-104418.
Abstract: The present study was carried out to evaluate the chemical and pharmacological properties of essential oil (EO) of Lavandula stoechas L. subsp. luisieri that is a spontaneous shrub widespread in Alentejo (Portugal). Oxygenated monoterpenes, as 1,8-cineole, lavandulol and necrodane derivatives are the main components of essential oil. It revealed important antioxidant activity with high ability to inhibit the lipid peroxidation and showed an outstanding effect against a wide spectrum of microorganisms, such as Gram-positive and Gram-negative bacteria and pathogenic yeasts. The analgesic effect studied in rats was dose dependent, reaching a maximum of 67 % at 60 min. with the dose of 200 mg/kg and the anti-inflammatory activity with this dose caused an inhibition in carrageenan-induced rat paw oedema (83 %) that is higher than dexamethasone 1 mg/Kg (69 %). Besides, animals exhibited a normal behaviour after EO administration revealing low toxicity. Essential oil of L. luisieri from Alentejo that presents important pharmacological properties and low toxicity is a promised candidate to be used as food supplement or in pharmaceutical applications.
URI: http://hdl.handle.net/10174/19835
ISSN: 0032-0943
Type: article
Appears in Collections:ICAAM - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
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