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|Title: ||Expeditious and novel synthesis of alpha-hydroxyesters via rhodium-NHC catalyzed arylation of ethyl glyoxalate|
|Authors: ||Burke, Anthony|
|Issue Date: ||1-Sep-2012|
|Publisher: ||PERGAMON-ELSEVIER SCIENCE LTD|
|Abstract: ||The rhodium-NHC catalyzed arylation reaction of ethyl glyoxalate with aryl and alkyl boronic acids provides an efficient method for the synthesis of alpha-hydroxyesters. A wide range of alpha-hydroxyesters (up to 12) were prepared in good to excellent yields. KO'Bu was the base of choice, along with tert-amyl alcohol as the solvent. As far as we are aware, this is the first report of this catalytic arylation, using rhodium-NHC catalysts with this specific substrate type|
|Appears in Collections:||CQE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica|
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