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|Title: ||LIPOSSARCOMA IN GUINEA PIG: A CASE REPORT|
|Authors: ||Guimarães, Tarcísio|
|Issue Date: ||20-Feb-2020|
|Publisher: ||Congresso Internacional Veterinário Montenegro|
|Citation: ||Guimarães, T., Cardoso, K., Moraes, J., Moraes, C., Botelho, F., Laranjo, M., Alexandre, N. (2020, 20 a 22 de Fevereiro de 2020). Lipossarcoma in guinea pig: a case report. XVI Congresso Internacional Veterinário Montenegro, Santa Maria da Feira, Portugal.|
Liposarcomas are malignant tumors of adipocytic differentiation1
, of rare incidence,
affecting animals and humans2
. According to the clinical and pathological characteristics
of liposarcoma, it can be classified into well-differentiated, undifferentiated, myxoid and
. Surgical excision is recommended, but recurrence4
and metastasis may
The objective of this study was to report case of a Guinea pig submitted to surgical
excision of a spontaneous liposarcoma.
A male Guinea pig (Cavia porcellus), 4 years old, was treated due to the presence
of a large cutaneous nodule, rapidly growing in the abdominal region. The semiological
evaluation showed a subcutaneous neoformation of 7 cm in diameter in the middle
abdominal region (left flank), firm in consistency, and non painfull on palpation. No other
noteworthy alterations in physiological parameters and complementary exams were
detected. The cytological findings on fine-needle aspiration puncture were compatible with
fatty tissue. Exeresis of the neoformation was advised and the animal was referred for
Pre-anesthesia sedation was performed with the combination of ketamine
hydrochloride(10mg/kg) and butorphanol(0,5mg/kg) via intramuscularly, and anesthetic
induction and maintenance was performed by inhalation using a mask), with isoflurane in
100% oxygen. Local anesthesia was performed at the incision line with 2% lidocaine,
administered subcutaneously with a 26G needle. In a continuous act, the surgical resection
of the neoformation occurred, presenting multilobulated aspect with yellowish-white color
and soft consistency. Surgical incision was closed with continuous suture with absorbable
thread(subcutaneous) and simple interrupted suture with non absorbable thread(skin).
Postoperative analgesia consisted of administration of meloxicam(0,1mg/kg, SC) for 2
days, tramadol hydrochloride(2,0 mg/kg, SC) for 3 days and antibiotherapy with
enrofloxacin(5,0mg/kg, SC) for 7 days.
The results of the histopathological examination revealed neoplasia composed of
fusiform mesenchymal cell bundles with multiple dilated spaces of fat, with
histopathological diagnosis of well differentiated Liposarcoma. After hospital treatment,
the animal showed excellent recovery, being discharged at after 7 days. It was referred for
further evaluation with the veterinary oncologist, reporting no complications during eight
months of follow-up.
Guinea pigs are popular as pets, being a species that can be affected by spontaneous
cutaneous and subcutaneous neoplasias. Taking in account the clinical evaluation of the
animal, surgical resection of the neoplasia was recommended. Although uncommon,
liposarcoma should be considered an anatomopathological differential diagnosis of
neoplasms that affect this species.
 Lee, A. T. J., Thway, K., Huang, P. H., & Jones, R. L. (2018). Clinical and Molecular Spectrum of
Liposarcoma. Journal of clinical oncology: official journal of the American Society of Clinical
Oncology, 36(2), 151-159.
 Quinton, J. F., Ollivier, F., & Dally, C. (2013). A case of well‐differentiated palpebral liposarcoma in a
Guinea pig (Cavia porcellus). Veterinary ophthalmology, 16, 155-159.
 Sahoo, A., Dwibedi, B., Das, J., Behera, M., & Behera, L. (2017). Spontaneous Liposarcoma in a Guinea
Pig (Cavia porcellus) and its Surgical Management. International Journal of Livestock Research, 1.
 Hoffman, A., Lazar, A. J., Pollock, R. E., & Lev, D. (2011). New frontiers in the treatment of
liposarcoma, a therapeutically resistant malignant cohort. Drug Resistance Updates, 14(1), 52-66.|
|Appears in Collections:||MVT - Comunicações - Em Congressos Científicos Internacionais|
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