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|Title: ||DIMETHYLPOLYSILOXANE AS AN OPTION FOR CLINICAL TREATMENT OF CORNEAL EDEMA IN A DOG WITH ENDOTHELIAL DISORDER: CASE REPORT|
|Authors: ||Guimarães, Tarcísio|
|Issue Date: ||20-Feb-2022|
|Publisher: ||Congresso Internacional Veterinário Montenegro|
|Citation: ||Guimarães, T., Cardoso, K., Botelho, F., Laranjo, M., Alexandre, N. (2020, 20 a 22 de Fevereiro de 2020).DIMETHYLPOLYSILOXANE AS AN OPTION FOR CLINICAL TREATMENT OF CORNEAL EDEMA IN A DOG WITH ENDOTHELIAL DISORDER: CASE REPORT. XVI Congresso Internacional Veterinário Montenegro, Santa Maria da Feira, Portugal.|
Corneal edema manifests as a diffuse blue-gray opacity. These corneal lesion is
due to increased water bonds between stromal collagen fibers4 and may occur secondary
to epithelial ulcerations, blood vessel growth and corneal endothelial disorders4. The
inciting mechanism is due to the loss or functional defect of the corneal endothelium and
results in a very diffuse edema4. When endothelial disorder is present, treatment with
topical medications and surgical procedures may be required. Dimethylpolysiloxane is an
ophthalmic lubricating compound3, which can also be used to treat bullous keratopathy1
and corneal edema2.
The aim of this study is to report the use of dimethylpolysiloxane in the treatment
of a dog with corneal edema secondary to endothelial disorder.
A female 5-year-old Pinscher dog was presented to consultation with a history of
opaque left eye. The patient was taking topical corticosteroid eye drops without
significant improvement. The use of 5% sodium chloride solution was not tolerated by
the animal and was discontinued. The ocular evaluation with slit lamp, showed a left eye
with diffuse corneal edema. Dazzle rand consensual pupillary reflexes were present. The
contralateral eye also presented discret central corneal opacity. Intraocular pressure (IOP)
was 17 mmHg and in the contralateral eye IOP was15 mmHg and ocular ultrasound was
unremarkable. There was no sign of inflammation or eye discomfort and sodium
fluorescein testing confirmed corneal integrity. Hematological and biochemical panel
results were within reference values for the specie.
Due to the clinical history and ophtalmological exam findings, it corneal edema
was attributed to an endothelial disorder, and the use of dimethylpolysiloxane Was
considered for topical treatment. Dimethylpolysiloxane manipulated eye drop
formulation as was prescribed, 4 times daily, until reassessment and dexamethasone eye
ointment 3 times daily, for 5 days.
Ten days after starting treatment with dimethylpolysiloxane, the animal responded
positively, presenting no complications. No eye discomfort was present, and significant
reduction in diffuse corneal edema observed. The edema was restricted to a central /
medial area of the cornea, with a slightly axial projection of these structure. It was
possible to evaluate the anterior chamber without observing any signs of inflammation.
In the contralateral eye no sign of edema was observed. Intraocular pressure was within
physiological parameters and ocular reflexes were present in both eyes. As the
progression of corneal edema, may result in corneal vascularization, pigmentation and
bullous keratitis, additional therapy with rho kinase inhibitor (ripasudil) was indicated in
left eye and surgical procedures such as thermokeratoplasty or conjunctival flap was
advised; however due to financial constraints the owner rejected. The use of
dimethylpolysiloxane eye drops was maintained 4 times daily for further reevaluations at
every 90 days.
Dimethylpolysiloxane promoted the reduction of corneal edema in a dog with
endothelial disorder, proving to be a good option for symptomatic treatment, especially
for animals that do not tolerate the use of hyperosmotic solutions.
 Tonelli Júnior, E., Pereira, M. V. C., Nery Júnior, F., & Pimentel, A. R. (1998). Hemorragia expulsiva
espontânea durante crise hepertensiva: relato de dois casos. Arq Bras oftalmol, 61(3), 266-70.
 Macedo, A. C., Ishirara, C., Fairbanks, D., Vitiello Neto, V., & Rehder, J. R. C. L. (2010).
Micropuncture with radiofrequency for the treatment of symptomatic bullous keratopathy. Revista
Brasileira de Oftalmologia, 69(3), 152-158.
 Batistuzzo, J., & Lima Filho, A. (2011). Formulações Magistrais em Oftalmologia. Acta Farmacêutica
Portuguesa, 1(1), 65-76.
 Maggs, D., Miller, P., & Ofri, R. (2017). Slatter's Fundamentals of Veterinary Ophthalmology E-Book.
Elsevier Health Sciences.
|Appears in Collections:||MVT - Comunicações - Em Congressos Científicos Internacionais|
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