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|Title: ||Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs|
|Authors: ||Ferreira, David A.|
Faustino-Rocha, Ana I.
Mesquita, João R.
Ortiz, Ana L.
|Issue Date: ||2018|
|Citation: ||Ferreira, David A.; Cruz, Rita; Venâncio, Carlos; Faustino-Rocha, Ana I.; Silva, Aura; Mesquita, João R.; Ortiz, Ana L.; Vala, Helena. Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs, Journal of Veterinary Science, 19, 5, 608-619, 2018.|
|Abstract: ||This work aimed to evaluate the effects on renal tissue integrity after hydroxyethyl starch (HES) 130/0.4 and Ringer’s lactate (RL)
administration in pigs under general anesthesia after acute bleeding. A total of 30 mL/kg of blood were passively removed from the femoral
artery in two groups of Large White pigs, under total intravenous anesthesia with propofol and remifentanil. After bleeding, Group 1 (n =
11) received RL solution (25 mL/kg) and Group 2 (n = 11) received HES 130/0.4 solution (20 mL/kg). Additionally, Group 3 (n = 6) was not
submitted to bleeding or volume replacement. Pigs were euthanized and kidneys were processed for histopathological and
immunohistochemical analyses. Minimal to moderate glomerular, tubular, and interstitial changes, as well as papillary necrosis, were observed
in all experimental groups. Pre-apoptosis and apoptosis indicators were higher in pigs that received HES 130/0.4, indicating a higher renal
insult. Both HES 130/0.4 and RL administration may cause renal injury, although renal injury may be more significant in pigs receiving HES
13/0.4. Results also suggest that total intravenous anesthesia with propofol and remifentanil may cause renal injury, and this effect can be
|Other Identifiers: ||1229-845X|
|Appears in Collections:||MVT - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica|
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