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Title: Biomarker evaluation and toxicological study of essential oils of Foeniculum vulgare and Calamintha nepeta
Authors: Piçarra, Andreia
Arantes, Silvia
Candeias, Fátima
Lopes, Orlando
Lima, Mónica
Tinoco, Teresa
Martins, Rosário
Keywords: Foeniculum vulgare
Calamintha nepeta
Essential oils
Toxicological evaluation
biochemical biomarkers
Issue Date: 2016
Publisher: Universidade de Évora, ICAAM
Citation: Piçarra A., Arantes S., Candeias M. F., Lopes O., Lima M., Tinoco M. T., Martins M. R. (2016). Biomarker evaluation and toxicological study of essential oils of Foeniculum vulgare and Calamintha nepeta. Proceedings of World Congress Silvo-Pastoral Systems 2016, University of Évora.
Abstract: The aim of this study was to evaluate the toxicological properties of EOs of F. vulgare and C. nepeta, widespread in Mediterranean agrosilvopastoral systems and often used as food condiments in Alentejo. EOs were obtained from aerial part of plants by hydrodistillation and chemical composition was evaluated by GC-FID. Toxicity of essential oils was evaluated by the estimation of LC50 in brine shrimp and LD50 in mice. Oral toxicity assays were performed in mice. Histological analyses and quantification of biomarkers aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyltransferase (γ-GT), bilirubin, creatinine and urea were performed for monitoring liver and kidney functions. the EOs of C. nepeta and F. vulgare showed very low toxicity suggesting their potential use as food supplement. Additionally, our studies point out the importance of the integration of C. nepeta and F. vugare in silvopastoral agroforestry systems, contributing to the animal health and profitability of livestock.
Type: article
Appears in Collections:MED - Artigos em Livros de Actas/Proceedings
QUI - Artigos em Livros de Actas/Proceedings
HERCULES - Artigos em Livros de Actas/Proceedings

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