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Title: TARTROL-derived chiral phosphine–phosphite ligands and their performance
Authors: Burke, Anthony
Dindaroglu, Mehmet
Schmalz, Hans-Günther
Akyol, Sema
Simsir, Hamza
Neudörfl, Jörg-Martin
Editors: Davies, Stephen
Keywords: Síntese
Issue Date: 15-Jun-2013
Abstract: By using (R,R,R,R)-2,3-dimethoxy-2,3-dimethyl-1,4-dioxane-5,6-bis-diphenylmethanol (TARTROL) as a chiral building block, a set of six modular phosphine–phosphite ligands (with a 1,2-phenylene backbone) were synthesized and evaluated in the Cu-catalyzed asymmetric 1,4-addition of Grignard reagents to cyclohexenone. Ligands with bulky substituents at the ortho- and para-positions to the chiral phosphite moiety were found to be the most selective affording the 1,4-addition products with enantioselectivities of up to 84% ee.
ISSN: 0957-4166
Type: article
Appears in Collections:CQE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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