DSpace Collection:
http://hdl.handle.net/10174/682
2024-03-29T07:13:26ZInternational Symposium on Synthesis and Catalysis 2019
http://hdl.handle.net/10174/26591
Title: International Symposium on Synthesis and Catalysis 2019
Authors: BURKE, Anthony
Editors: Burke, Anthony; Marques, Carolina; Carreiro, Elisabete
Abstract: This is the book of abstracts for the 3rd edition of ISySyCat2019 that took place from 3 to 6 September 2019. http://isysycat2019.eventos.chemistry.pt/2019-08-14T23:00:00ZPd-Catalyzed One-Pot Borylation/Intramolecular Asymmetric Arylation on α-Ketiminoamides: Innovative Approach to Chiral 3-Amino-2-oxindoles
http://hdl.handle.net/10174/24681
Title: Pd-Catalyzed One-Pot Borylation/Intramolecular Asymmetric Arylation on α-Ketiminoamides: Innovative Approach to Chiral 3-Amino-2-oxindoles
Authors: Burke, Anthony; Marques, Carolina; Lawrence, Simon
Editors: List, Benjamin
Abstract: 3-Amino-2-oxindole derivatives are a common framework found in many natural products and medicinal compounds and thus their synthesis is of significant importance. We report for the first time a one-pot approach for the synthesis of these compounds, using a borylation/intramolecular asymmetric arylation sequence starting from ortho-bromo-alpha-ketimino amide derivatives. Pd(OAc)(2) was used as the pre-catalyst along with (R)-BINAP as the chiral source. We successfully obtained a family of 3-phenyl-3-(aryl-amino)-indolin-2-one derivatives (11 in total) with excellent yields (up to 98%) and enantioselectivities of up to 76% ee. The reaction is versatile and tolerant of a wide range of functional groups.2018-03-01T00:00:00ZRecent advances in the asymmetric catalytic synthesis of chiral 3-hydroxy and 3-aminooxindoles and derivatives: Medicinally relevant compounds
http://hdl.handle.net/10174/24676
Title: Recent advances in the asymmetric catalytic synthesis of chiral 3-hydroxy and 3-aminooxindoles and derivatives: Medicinally relevant compounds
Authors: Burke, Anthony; Brandão, Pedro
Editors: Motherwell, Willian; Zard, Samir
Abstract: Several oxindole derivatives, of natural or synthetic origin, have been identified as medicinally appealing compounds, with a plethora of bioactivities reported. Chiral 3-hydroxy and 3-aminooxindole scaffolds have captured the attention of several research groups, due to their importance in drug discovery. In this review, we systematically address the wide variety of asymmetric catalytic methodologies employed in the preparation of these relevant chiral scaffolds, present in many biologically active compounds and/or natural products. Special focus will be given to the nature of the catalyst used.2018-09-19T23:00:00ZActive Pharmaceutical Ingredients in Synthesis, Catalytic Processes in Research and Development
http://hdl.handle.net/10174/24675
Title: Active Pharmaceutical Ingredients in Synthesis, Catalytic Processes in Research and Development
Authors: Burke, Anthony; Marques, Carolina; Herrman, Gesine; Turner, Nicholas
Abstract: Um livro sobre a aplicação de catalisadores na produção de moléculas biologicamente ativos e fármacos2018-08-31T23:00:00Z