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http://hdl.handle.net/10174/7208
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Title: | Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines |
Authors: | Mendes, Paulo J. |
Keywords: | Organometallic Complexes Anticancer |
Issue Date: | 2012 |
Publisher: | PubMed |
Citation: | Tânia S. Morais, Tiago J. L. Silva, Fernanda Marques, Isabel Santos, M. Paula Robalo, Fernando Avecilla, Paulo J. Amorim Madeira, Paulo J.G. Mendes, M. Helena Garcia; “Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines” Journal of Inorganic Biochemistry, 2012, 114, 65-74 doi: 10.1016/j.jinorgbio.2012.04.014 |
Abstract: | A new family of "RuCp" (Cp=η(5)-C(5)H(5)) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PC3. IC(50) values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data. |
URI: | http://www.ncbi.nlm.nih.gov/pubmed/22698866 http://hdl.handle.net/10174/7208 |
Type: | article |
Appears in Collections: | QUI - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica CQE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
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