Please use this identifier to cite or link to this item:
http://hdl.handle.net/10174/4027
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| Title: | Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and characterization |
| Authors: | Teixeira, Fátima C.
Antunes, Inês F.
Curto, M. João M.
Neves, M.
Teixeira, António P. S. |
| Keywords: | Bisphosphonates
Indazoles
N-1 and N-2 isomers,
spectroscopic characterization |
| Issue Date: | 2009 |
| Publisher: | Arkat USA, Inc |
| Abstract: | Bisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium
metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted
at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,1-bisphosphonates were
synthesized from the corresponding carboxylic acid or acyl chloride compounds, by two
different methods. These BPs have a side chain with different lengths ((CH2)n, n = 0-5) between
the indazole ring and the bisphosphonate group. |
| URI: | http://hdl.handle.net/10174/4027 |
| ISSN: | 1551-7012 |
| Type: | article |
| Appears in Collections: | QUI - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
CQE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
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CQE - Centro de Química de Évora /
CQE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica /
