Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/31029

Title: Interaction between intense pulsed light and skin: data from an animal model
Authors: Faustino-Rocha, Ana Isabel
Ferreira, Rita
Pires, Maria João
Gama, Adelina
Oliveira, Paula Alexandra
Issue Date: 2021
Citation: Faustino-Rocha AI, Ferreira R, Pires MJ, Gama A, Oliveira PA. 2021. Interaction between intense pulsed light and skin: data from an animal model. International E-Conference on Dermatology and Cosmetology, p.5, 10 de maio.
Abstract: Background: Although its effects remain unknown, the intense pulsed light (IPL) has been extensively used in dermatology and esthetics. Purpose: This study aimed to address the impact of IPL in neoplastic lesions using an animal model. Methodology: All experiments followed the European and National legislation. Sixteen ICR female DBA/2JRccHsd mice were randomly assessed to two experimental groups: IPL-exposed (n=8) and non-exposed (n=8). The mice dorsal region was shaved using a machine clipper. The carcinogen 7,12-dimethylbenz[a] anthracene (DMBA; 2mM, single dose) and 12-O-tetradecanoylphorbol-13-acetate (TPA; 100mM, twice a week, for 22 weeks) were applied to all animals. Moreover, IPL-exposed animals were applied with IPL (intensity of 2J/cm2, twice a week, for 22 weeks). At the sacrifice, skin samples were collected and processed for histological analysis. Data was analyzed with SPSS. Results: IPL-exposed mice developed a lower number of skin lesions when compared with non-IPL-exposed animals (28 versus 46 lesions) (p=0.036). Each group presented 8 preneoplastic epidermal lesions (epidermal hyperplasia). The number of neoplastic lesions was lower in IPL-exposed mice than in non-IPL-exposed ones (20 versus 38 lesions) (p=0.018). Papilloma grade II was the neoplastic epidermal lesion most frequently observed in both groups (9 in IPL-exposed mice versus 19 in non-IPL-exposed mice) (p=0.059). Despite this, the number of microinvasive squamous carcinoma was higher in IPL-exposed animals (3 in IPL-exposed mice versus 1 in non-IPL-exposed mice). Conclusion: The results suggest that IPL exposition may inhibit skin carcinogenesis, but its use may promote malignant conversion of skin lesions.
URI: http://hdl.handle.net/10174/31029
Type: article
Appears in Collections:ZOO - Artigos em Livros de Actas/Proceedings

Files in This Item:

File Description SizeFormat
IPL skin.pdf1.65 MBAdobe PDFView/Open
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Dspace Dspace
DSpace Software, version 1.6.2 Copyright © 2002-2008 MIT and Hewlett-Packard - Feedback
UEvora B-On Curriculum DeGois