The Portuguese national registry of Congenital Anomalies receives notifications from medical specialists that identify CA in live births, fetal deaths or stillbirths and in the context of induced abortions due to a fetal malformation. Data on gestation period (including pre-natal diagnosis), personal and familiar history, description of anomalies, laboratory findings, socio-economic and geographic dimensions is also reported. The aim of this work is to study the spatial and temporal patterns of occurrences of CA and the associations of explanatory variables or factors that could influence CA rates.